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Bosentan

Uses

Bosentan is used in the treatment of pulmonary arterial hypertension (PAH).

How it Works

How Bosentan works Bosentan is an endothelin receptor blocker that inhibits the action of endothelin, a natural substance that causes blood vessels to constrict. This constriction increases the pressure in the blood vessels of the lungs. Bosentan helps relax these blood vessels and enhances the blood supply to the lungs.

Side Effects

Common side effects of Bosentan include respiratory tract infection, headache, flushing (a sense of warmth in the face, ears, neck, and trunk), and fluid retention.

Expert Advice

  • Your doctor has prescribed Bosentan to treat high blood pressure in the vessels that carry blood from the heart to the lungs (the pulmonary arteries).
  • It helps improve your quality of life, exercise ability, and delays disease progression.
  • Notify your doctor if you are pregnant, planning to conceive, or breastfeeding.
  • Your doctor may request routine blood tests to check for anemia and assess liver function.
  • Do not drive or engage in activities requiring concentration until you know how Bosentan affects you.
  • Females with reproductive potential should use a reliable form of birth control while using Bosentan and for one month after stopping, as it is toxic to an unborn baby.
  • Inform your doctor if you experience:
    • Weight gain
    • Swelling of your arms and legs
    • Difficulty breathing
  • Inform your doctor if you notice:
    • Yellowing of the skin or eyes
    • Dark urine
    • Stomach pain

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Frequently asked questions

Bosentan is administered as a tablet taken twice daily, in the morning and evening, with or without food. The specific dosage is determined by the doctor based on the patient's age and weight.
Bosentan is not safe during pregnancy as it can cause major birth defects. It is advised to avoid this medication if planning to become pregnant and to use reliable contraception. Consult your doctor before starting Bosentan or planning a pregnancy.
Yes, Bosentan can cause anemia due to a dose-related decrease in hemoglobin levels. Regular hemoglobin monitoring is recommended, and consultation with the prescribing doctor is advised. In some cases, blood transfusions may be necessary to treat anemia.
Bosentan may cause liver damage and increase liver enzymes, particularly in patients with liver disease. It should be used cautiously in such cases, and patients should inform their doctor of any liver history before starting the medication.
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