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Baricitinib

Uses

Baricitinib is used in the treatment of rheumatoid arthritis.

How it Works

How Baricitinib works Baricitinib is a Janus kinase (JAK) inhibitor that blocks the activity of selective JAK1 and JAK2 enzymes. This interference affects the JAK-STAT signaling pathway, which is a series of protein-cell interactions involved in processes such as immunity, cell division, cell death, and tumor formation.

Side Effects

Common side effects of Baricitinib include upper respiratory tract infection, nasopharyngitis (inflammation of the throat and nasal passages), urinary tract infection, bronchitis (inflammation of the airways), and headache.

Expert Advice

  • Baricitinib is used alone or in combination with methotrexate for the treatment of rheumatoid arthritis that has not improved with other anti-rheumatic drugs.
  • It may take 3 to 6 months to experience the maximum effect of this medication.
  • Continue taking it as prescribed.
  • Your doctor may conduct regular blood tests to monitor:
    • Liver function
    • Kidney function
    • Blood counts
    • Cholesterol levels
  • Baricitinib can make it somewhat harder for individuals to fight off infections.
  • Inform your doctor if you experience symptoms of an infection, such as:
    • Fever
    • Chills
    • Cough
    • Muscle aches
  • Your doctor may conduct a TB (tuberculosis) skin test and a chest X-ray before starting treatment with this medication.
  • Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

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Frequently asked questions

Baricitinib may elevate the risk of certain cancers, including lymphoma and skin cancers, by impacting the immune system. Notify your doctor if you have a history of any type of cancer.
Inform your doctor about any liver problems before starting Baricitinib, as it may increase liver enzymes. While Baricitinib can be used in patients with mild to moderate liver impairment, it is contraindicated in those with severe liver impairment.
You may need blood tests before or during Baricitinib treatment to check for anemia, low white blood cell counts, high cholesterol, or elevated liver enzymes. Additionally, your doctor may recommend testing for tuberculosis, as Baricitinib could worsen existing infections.
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