Aspirin and caffeine are used in the treatment of headaches.
How Aspirin and Caffeine Work Aspirin and Caffeine is a combination of two medications that relieve headaches. Aspirin works by blocking the release of certain chemical messengers that cause fever, pain, and inflammation (redness and swelling). Caffeine narrows the blood vessels in the brain to help reduce headaches.
Common side effects of Aspirin and Caffeine include nausea, stomach pain, indigestion, increased heart rate, restlessness, and heartburn.
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