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Apremilast

Uses

Apremilast is used in the treatment of plaque psoriasis. It is indicated for patients who have had an inadequate response or have been intolerant to a previous medication.

How it Works

How Apremilast works Apremilast is a phosphodiesterase 4 (PDE4) inhibitor. It functions by blocking the action of specific chemical messengers that are responsible for inflammation associated with psoriatic arthritis and psoriasis, thereby reducing the signs and symptoms of these conditions.

Side Effects

Common side effects of Apremilast include diarrhea, nausea, vomiting, upper respiratory tract infection, headache, tension headache, bronchitis (inflammation of the airways), nasopharyngitis (inflammation of the throat and nasal passages), decreased appetite, insomnia (difficulty sleeping), depression, migraine, cough, dyspepsia, increased bowel movements, upper abdominal pain, gastroesophageal reflux disease, back pain, fatigue, tooth abscess, hair follicle inflammation, and joint pain.

Expert Advice

  • Apremilast is a well-tolerated medication.
  • Mild stomach upset may occur early during treatment.
  • Regularly monitor your weight, as Apremilast may cause weight loss.
  • Your doctor will gradually increase the dose from day 1 to day 6 of treatment, after which it may be maintained at a constant level.
  • Inform your doctor immediately if you experience:
    • New or worsened depression
    • Suicidal thoughts
    • Other mood changes
    • Unexplained weight loss

Other Combinations

Apremilast + Apremilast + Apremilast

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Frequently asked questions

Yes, Apremilast may decrease appetite, potentially leading to weight loss. Regular weight monitoring is advised, and significant weight loss should be discussed with a doctor.
Take Apremilast exactly as prescribed by your doctor, starting with a low dose that is gradually increased after 6 days. Swallow the tablets whole with water, and they can be taken with or without food.
No, Apremilast is not an immunosuppressant. It is a phosphodiesterase 4 inhibitor (PDE4) that reduces inflammation by blocking the activity of PDE4 in inflammatory cells.
No, rifampicin should not be taken with Apremilast as it can lower the effectiveness of Apremilast by decreasing its levels in the body.
Yes, Apremilast may cause depression and suicidal thoughts. It should be avoided in individuals with a history of depression, and any concerning symptoms should prompt immediate consultation with a doctor.
If you become pregnant while taking Apremilast, inform your doctor immediately. Pregnancy should be avoided during treatment due to potential risks of baby loss or defects based on animal studies.
Apremilast, used for plaque psoriasis and psoriatic arthritis, is a long-term treatment that may take approximately 16 weeks to show improvement.
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