Flat ₹100 OFF on First app order   |    Use Code:  APP100   | 

Flat ₹100 OFF
on First app order

Use Code
APP100

Download Now

AppleIconPlayStoreIcon

Amitriptyline

Uses

Amitriptyline is used in the treatment of depression, anxiety, bed-wetting, migraine, obsessive-compulsive disorder, insomnia, and neuropathic pain.

How it Works

How Amitriptyline works Amitriptyline is a tricyclic antidepressant that possesses anticholinergic and sedative properties. It prevents the reuptake and subsequent inactivation of neurotransmitters called noradrenaline and serotonin, which are present at the nerve terminals in the brain. By inhibiting the reuptake of these monoamine neurotransmitters, Amitriptyline enhances their action in the brain. This mechanism is thought to be associated with its antidepressant effects and helps regulate mood. Additionally, it blocks the transmission of pain signals from nerves to the brain, thereby relieving neuropathic pain, which originates from damaged nerves.

Side Effects

Common side effects of Amitriptyline include constipation, dry mouth, orthostatic hypotension (sudden lowering of blood pressure upon standing), weight gain, aggressive behavior, nasal congestion (stuffy nose), sleepiness, dizziness, headache, decreased libido, nausea, fatigue, confusion, tremors, speech disorders, palpitations, changes in taste, paresthesia (tingling or pricking sensation), abnormalities of voluntary movements, loss of accommodation, atrioventricular block, micturition disorders, erectile dysfunction, abnormal ECG, and decreased sodium levels in the blood.

Expert Advice

  • It may take 4 to 6 weeks for Amitriptyline to start working.
  • Continue taking it as prescribed.
  • It may cause sleepiness; take it at bedtime.
  • Do not drive or engage in activities requiring concentration until you know how it affects you.
  • Avoid consuming alcohol while taking Amitriptyline, as it may cause excessive sleepiness.
  • Monitor your weight during treatment, as this medication can cause weight gain and increased appetite.
  • Amitriptyline may cause a sudden drop in blood pressure; rise slowly if you have been sitting or lying down.
  • Consult your doctor if you notice sudden mood changes or develop suicidal thoughts.
  • Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings.
  • This is particularly important when starting an antidepressant or changing the dose.
  • The main dose should be taken at night, as this medication may produce drowsiness or sleepiness.
  • It can take 2 to 3 weeks for Amitriptyline to start working.
  • Continue the treatment for at least 6 months after feeling better to prevent depression from returning.
  • If your doctor advises you to stop Amitriptyline, reduce the dose slowly over 4 weeks.
  • Do not discontinue it abruptly.
  • Avoid driving or operating machinery, as it may decrease alertness.
  • Avoid alcohol consumption while taking Amitriptyline, as it may cause excessive drowsiness and calmness.
  • The potential for addiction or dependence on Amitriptyline is very low.
  • Overdose may be extremely dangerous.

Other Combinations

Amitriptyline + Chlordiazepoxide

Amitriptyline + Gabapentin

Amitriptyline + Ketamine

Amitriptyline + Pantoprazole

Amitriptyline + Pregabalin

Amitriptyline + Propranolol

Amitriptyline + Vitamin B12 (Methylcobalamin)

Frequently asked questions

Yes, Amitriptyline can cause urinary problems, particularly in patients over 65. Difficulty passing urine may occur, potentially leading to urinary tract infections. Consult your doctor if you experience these symptoms.
Yes, Amitriptyline can affect sexual function in both genders, potentially causing decreased libido, discomfort during intercourse, erectile difficulties in men, and issues with orgasm. If you experience these side effects, consult your doctor rather than discontinuing the medication.
No, do not stop taking Amitriptyline even if your pain improves. Follow your doctor's advice regarding the duration of treatment, as abrupt discontinuation may lead to withdrawal symptoms. Consult your doctor for a gradual reduction in dosage.
Amitriptyline helps gradually improve your mood, leading to better sleep and reduced anxiety. You may find yourself less troubled by minor issues, but it will not induce excessive happiness; rather, it will help you feel like yourself again.
You may notice improvements within a couple of weeks, but it generally takes 4-6 weeks to feel significant benefits. Do not discontinue the medication prematurely; allow at least 6 weeks for it to work.
Amitriptyline can cause drowsiness and dizziness, especially at the start of treatment. Avoid driving or operating machinery until you understand how it affects you, and refrain from alcohol consumption as it may enhance drowsiness.
You may begin to feel better within 2 weeks of starting Amitriptyline, but it typically takes 4-6 weeks to experience the full benefits.
Amitriptyline should not be taken during pregnancy unless prescribed by a doctor. If used in the third trimester, it may cause symptoms in the newborn, such as irritability and difficulty feeding.
To maximize the benefits of Amitriptyline, maintain an active lifestyle, eat a healthy diet, think positively, and discuss your feelings with others to reduce stress. Engage in hobbies or yoga, ensure adequate sleep, and avoid smoking and alcohol. Always take your medication as prescribed, even if you start feeling better.
If you experience thoughts of self-harm or suicide, seek immediate help from your doctor or go to the hospital. These thoughts may arise due to your condition or the medication, particularly in individuals with a history of suicidal tendencies or those under 25 years old.
No, do not exceed the prescribed dose of Amitriptyline. Overdosing can lead to serious side effects such as drowsiness, confusion, and respiratory difficulties. Pain relief may take time, so consult your doctor if symptoms do not improve.
;