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Ambrisentan

Uses

Ambrisentan is used in the treatment of pulmonary arterial hypertension (PAH).

How it Works

How Ambrisentan Works Ambrisentan is an endothelin receptor blocker. It inhibits the action of endothelin, a natural substance that causes blood vessels to narrow. This narrowing increases the pressure in the blood vessels of the lungs. Ambrisentan helps to relax these blood vessels and enhances the blood supply to the lungs.

Side Effects

Common side effects of Ambrisentan include sinus inflammation, nasal congestion (stuffy nose), peripheral edema, and flushing (a sense of warmth in the face, ears, neck, and trunk).

Expert Advice

  • Your doctor has prescribed Ambrisentan to treat high blood pressure in the vessels that carry blood from the heart to the lungs (the pulmonary arteries).
  • Ambrisentan helps to improve your quality of life, exercise ability, and delay disease progression.
  • Your doctor may request routine blood tests to check for anemia and assess liver function.
  • Do not drive or engage in activities requiring concentration until you know how Ambrisentan affects you.
  • Females with reproductive potential should use a reliable form of birth control while taking Ambrisentan and for 1 month after stopping, as it can be toxic to an unborn baby.
  • Notify your doctor if you are pregnant, planning to conceive, or breastfeeding.
  • Inform your doctor if you experience weight gain, swelling of your arms and legs, or difficulty breathing.
  • Report any yellowing of the skin or eyes, dark urine, or stomach pain to your doctor.

Other Combinations

Ambrisentan + Tadalafil

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Frequently asked questions

Ambrisentan is usually taken as a single daily dose, with or without food. It should be swallowed whole with a glass of water and not crushed, chewed, or broken.
Yes, Ambrisentan can increase liver enzymes and may rarely cause liver injury or autoimmune hepatitis. Consult your doctor if you experience nausea, vomiting, loss of appetite, dark urine, or yellowing of the skin.
Ambrisentan is prescribed to treat pulmonary hypertension, a condition characterized by increased blood pressure in the pulmonary arteries. It helps lower this pressure by relaxing the arteries, easing the heart's workload.
No, do not stop taking Ambrisentan without consulting your doctor, as it may worsen your condition. Discuss any need to discontinue with your doctor.
Serious side effects include fluid retention, decreased sperm count, and anemia. Inform your doctor of any unusual weight gain, fatigue, or breathing difficulties.
Overdosing on Ambrisentan may lead to headache, flushing, dizziness, nausea, and low blood pressure, which can cause lightheadedness. Seek immediate medical assistance if you exceed the recommended dose.
Ambrisentan can cause serious birth defects if taken during pregnancy. Women capable of becoming pregnant should have a pregnancy test before starting treatment and use two reliable contraception methods during treatment.
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