Istamet XR 1000/100mg Tablet 10s

Istamet Xr 1000 100mg Tablet 10s is an oral anti-diabetic combination medication containing Metformin (a biguanide) and Sitagliptin (a DPP-4 inhibitor). It is used to improve glycaemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise. This combination is typically prescribed when blood sugar levels are not adequately controlled by a single medicine alone. By combining two medicines with distinct yet complementary mechanisms, Istamet Xr 1000 100mg Tablet 10s effectively lowers both fasting and post-meal blood glucose levels. It is primarily available as oral tablets, including immediate-release and extended-release (ER/XR) formulations.

Istamet Xr 1000 100mg Tablet 10s is a prescription medicine used to help control blood sugar levels in adults with type 2 diabetes mellitus. It contains two active ingredients that work in complementary ways to improve glucose regulation.

Metformin belongs to the biguanide class. It lowers blood sugar by reducing glucose production in the liver, improving the body’s sensitivity to insulin, and slowing the absorption of sugar from food in the intestines. Sitagliptin is a dipeptidyl peptidase‑4 (DPP‑4) inhibitor. It increases the levels of natural incretin hormones, which help the pancreas release more insulin after meals and reduce the amount of glucose produced by the liver.

This combination is prescribed when diet, exercise, and single‑agent therapy are not sufficient to achieve adequate blood sugar control. By working together, Metformin and Sitagliptin may help lower blood sugar throughout the day, particularly after meals, and may reduce the risk of long‑term complications of type 2 diabetes, such as cardiovascular disease, chronic kidney disease, and diabetic neuropathy.

Your doctor will determine the most appropriate dose and formulation for your condition, and regular monitoring of blood sugar and kidney function is usually recommended during treatment.

Istamet Xr 1000 100mg Tablet 10s may be indicated by your doctor for:

Type 2 Diabetes Mellitus

To improve blood sugar control in adults who are not sufficiently controlled on metformin or sitagliptin alone.

Replacement Therapy

For patients already stabilised on separate doses of metformin and sitagliptin.

Initial Therapy

In some clinical cases, the patient's baseline blood sugar levels are high enough to require dual therapy from the start.

Istamet Xr 1000 100mg Tablet 10s may provide benefits such as:

• Dual‑action glucose-lowering that targets both liver glucose output and pancreatic insulin response

• Significant reduction in HbA1c, supporting achievement of target glycaemic goals

• Lower risk of hypoglycaemia compared to some other classes of diabetes medications, like sulfonylureas

• Weight‑neutral profile with minimal risk of weight gain

• Favourable safety record with good tolerability in most patients

• Simplified treatment schedule through a single combination tablet, available in immediate‑release and extended‑release (ER/XR) formulations

Istamet Xr 1000 100mg Tablet 10s is generally well-tolerated, but side effects can occur, particularly during the initiation of therapy.

Common side effects of Istamet Xr 1000 100mg Tablet 10s may include

• Stomach upset, nausea, or diarrhoea

• Mild headache

• Cold‑like symptoms such as a runny nose or sore throat

Uncommon side effects of Istamet Xr 1000 100mg Tablet 10s may include

• Skin rash or itching

• Joint or muscle pain

• Changes in taste

• Mild swelling of hands or feet

Serious side effects that may require immediate medical attention include

• Lactic acidosis: a rare but serious build‑up of acid in the blood (symptoms may include severe tiredness, muscle pain, or difficulty breathing)

• Pancreatitis: inflammation of the pancreas (symptoms may include severe abdominal pain that may radiate to the back)

• Liver function changes: rare elevations in liver enzymes that may require monitoring

• Severe allergic reactions: swelling of the face, lips, or throat, or difficulty breathing

Always consult your doctor if you notice any unusual symptoms while taking Istamet Xr 1000 100mg Tablet 10s.

Use Istamet Xr 1000 100mg Tablet 10s exactly as directed by your doctor.

• Take the tablet with meals to help reduce the risk of stomach upset or diarrhoea

• Usually taken once or twice daily, depending on the formulation (immediate‑release or extended‑release) and your doctor’s advice

• Swallow the extended‑release (ER/XR) tablets whole. Do not crush, chew, or break them

• Try to take your medication at the same time each day to maintain consistency

• Regularly check your blood sugar as instructed by your healthcare provider

• Do not stop taking Istamet Xr 1000 100mg Tablet 10s unless advised by your doctor

Istamet Xr 1000 100mg Tablet 10s helps control blood sugar in type 2 diabetes by combining two medicines with different actions.

Metformin lowers the amount of glucose produced by the liver, improves the body’s sensitivity to insulin, and slows the absorption of sugar from food in the intestines.

Sitagliptin increases levels of natural hormones (incretins) that stimulate the pancreas to release more insulin after meals and reduce the amount of glucose made by the liver.

Together, these actions help maintain steadier blood sugar levels throughout the day, especially after eating, and support long‑term management of type 2 diabetes.

Store Istamet Xr 1000 100mg Tablet 10s at room temperature in a dry place away from direct sunlight and heat.

• Keep the tablets in their original container or blister pack.

• Do not store in the bathroom where moisture levels are high.

• Keep out of the reach of children and pets.

• Do not use after the expiry date.

Taking more than the prescribed dose of this medicine can be harmful. An overdose can cause severe stomach upset or lead to lactic acidosis and low blood sugar. If you suspect an overdose, contact emergency medical services or a poison control centre immediately.

Take the missed dose as soon as you remember with food. If it is almost time for your next dose, skip the missed one and return to your regular schedule. Do not take two doses at the same time to make up for a missed application.