Sizon 20mg Tablet

Sizon 20mg Tablet is a highly effective, advanced second-generation antihistamine used to manage and relieve symptoms of various allergies. Containing Levocetirizine five mg, it provides fast and consistent 24-hour relief from common allergic reactions such as hay fever (seasonal allergic rhinitis), persistent year-round allergies, and chronic skin conditions like hives (idiopathic urticaria). By blocking the action of natural histamine, Sizon 20mg Tablet significantly reduces sneezing, a runny nose, watery eyes, and skin itching, allowing patients to maintain their daily routine without the discomfort of allergies.

Sizon 20mg Tablet is a trusted, dual-action medication prescribed for the comprehensive and long-term control of both respiratory and dermatological allergic conditions. The active pharmaceutical ingredient, Levocetirizine, is a potent, selective H1-receptor antagonist. It is the active enantiomer of the older antihistamine, Cetirizine, which makes it effective at a lower dose, with an improved side-effect profile, particularly a reduced tendency to sedation.

The body’s natural defence mechanism against environmental triggers like pollen, dust mites, or pet dander involves releasing a chemical called histamine. Histamine binds to H1 Receptors, triggering a cascade of uncomfortable allergy symptoms—inflammation, fluid leakage leading to a runny nose, and intense itching. Sizon 20mg Tablet works by powerfully and selectively binding to these peripheral H1-receptors, effectively preventing histamine from attaching and exerting its adverse effects.

This inhibition not only provides symptomatic relief but also helps stabilise the allergic response. Consistent, once-daily administration helps keep the body's histamine levels in check throughout the day and night. This medicine requires a prescription and should always be used under the guidance of a registered healthcare professional to ensure correct dosage and duration.

Sizon 20mg Tablet (Levocetirizine) is prescribed for the following clinical indications:

• Treatment of Seasonal Allergic Rhinitis (Hay Fever): Effectively relieves nasal congestion, sneezing, nasal itching, and watery, itchy eyes caused by seasonal allergens such as pollen.

• Management of Perennial Allergic Rhinitis: Provides year-round relief from chronic allergy symptoms triggered by non-seasonal allergens such as pet dander, mould spores, and house dust mites.

• Relief from Chronic Idiopathic Urticaria (Chronic Hives): Significantly reduces the uncomfortable symptoms of itching (pruritus), swelling, and the appearance of persistent red, raised welts associated with chronic hives of unknown cause.

• Treatment of Allergic Skin Manifestations: Used to alleviate itching and rash associated with various acute and chronic non-infectious allergic skin reactions.

Choosing Sizon 20mg Tablet provides essential allergy management advantages:

• Maximum Potency: Delivers powerful H1-receptor blockade at a low five mg dose, ensuring high efficacy.

• Twenty-Four Hour Control: Just one tablet daily provides sustained symptom relief for a full day.

• Low Sedation Risk: As a second-generation antihistamine, it has minimal drowsiness risk, helping you stay alert.

• Rapid Action: Works quickly, initiating relief often within 60 minutes of the first dose.

• Enhances Sleep: Controls nocturnal symptoms like itching and post-nasal drip, improving overall sleep quality.

While Sizon 20mg Tablet is generally well-tolerated, some individuals may experience side effects. The severity and occurrence of side effects are often dose-related and temporary. If any of these effects persist or worsen, consult your doctor.

Common Side Effects (May occur in more than one in ten people):

• Drowsiness, fatigue, or tiredness (somnolence).

• Dry mouth (xerostomia).

• Headache.

• Inflammation of the pharynx (sore throat).

Uncommon or Rare Side Effects (Require medical attention if severe):

• Gastrointestinal upset: Nausea, vomiting, or abdominal pain.

• Hypersensitivity Reaction: Swelling of the face, lips, tongue, or throat (angioedema), difficulty breathing, or severe rash—requires immediate emergency care.

• Vision disturbances.

• Difficulty or inability to pass urine (urinary retention).

• Irregular heartbeat (tachycardia).

Follow your doctor's instructions precisely when taking Sizon 20mg Tablet.

• Swallow the tablet whole with a sufficient amount of water. Do not crush, chew, or break the tablet, as this can affect its release mechanism.

• The medicine can be taken with or without food.

• It is typically taken once daily. For patients who experience mild drowsiness, taking the dose in the evening or before bedtime is often recommended.

• Do not exceed the dosage or duration prescribed by your doctor. If your symptoms do not improve after the prescribed course, seek further medical advice.

• Take the entire course of Sizon 20mg Tablet as prescribed by your doctor, even if your symptoms have completely resolved.

• If you feel drowsy, switch your dose to the evening or just before bed.

• Avoid consuming alcohol while on this medication to minimise the risk of increased sedation and dizziness.

• Be cautious when performing tasks that require concentration, such as driving, until you know how the medicine affects you.

• Always inform your doctor or pharmacist about any other medications, including herbal supplements, you are currently taking.

• Store Sizon 20mg Tablet at room temperature, ideally below twenty-five degrees Celsius.

• Keep the medicine in a cool, dry place, protected from direct sunlight, heat, and excessive moisture.

• Always keep the medication out of the sight and reach of children and pets.

• Do not use the medicine if the expiry date printed on the pack has passed or if the packaging shows signs of tampering.

Sizon 20mg Tablet (Levocetirizine) exhibits a favourable profile regarding food interactions. The absorption and efficacy of the five mg dose are not significantly altered by the presence of food, meaning the tablet can be taken at any time relative to meals.

Always provide your doctor with a complete list of all medications, supplements, and herbal products you are taking before starting Sizon 20mg Tablet.

• CNS Depressants: The most critical interaction is with other CNS depressants. This includes sedatives, tranquillisers (anxiolytics), hypnotics (sleep aids), opioid painkillers, and certain anti-depressants. Combining these with Sizon 20mg Tablet increases the risk of excessive drowsiness, respiratory depression, and confusion.

• Theophylline: Co-administration of Levocetirizine with the bronchodilator Theophylline has been shown to result in a minor decrease in Levocetirizine clearance, potentially leading to slightly higher drug levels.

• Ritonavir: The anti-HIV medicine Ritonavir can increase levocetirizine levels in the blood by altering its kidney clearance, potentially increasing the risk of side effects.

• Other Antihistamines: You must avoid combining Sizon 20mg Tablet with any other medicines containing antihistamines (e.g., in some cold and flu preparations, or older generation allergy medications) to prevent an accidental overdose.

Patients with certain underlying medical conditions may require dosage adjustments or close monitoring when taking Sizon 20mg Tablet.

• Renal Impairment (Kidney Disease): This is the most significant disease interaction. Levocetirizine is primarily eliminated unchanged by the kidneys. Therefore, patients with moderate to severe kidney impairment (renal failure) will accumulate the drug, necessitating a reduced dosage and/or less frequent dosing schedule.

• Urinary Retention: Due to its mild anticholinergic-like effect, Sizon 20mg Tablet should be used with caution in patients with conditions that predispose them to urinary retention, such as benign prostatic hyperplasia (prostate enlargement) or spinal cord lesions.

• Epilepsy/Seizure Disorders: There have been rare reports of seizures in patients taking Levocetirizine. Caution and close monitoring are advised for individuals with a history of Epilepsy or other seizure disorders.

• Liver Disease: Although the liver minimally metabolises the drug, caution is still advisable in patients with severe liver impairment, and consultation with a specialist is often recommended.

The standard recommended dose of Levocetirizin, five mg, is one tablet taken once daily in the evening.

• Adults and Adolescents (12 years and older): Five mg once daily.

• Children (6 to 11 years): The standard dose is 2.5mg once daily (often administered as an oral solution or a half tablet, depending on the formulation).

Your healthcare provider will determine the most appropriate dosage and duration of treatment based on your age, the severity of your allergy symptoms, and the status of your kidney function. Never self-adjust the prescribed dosage.

If you miss a dose of Sizon 20mg Tablet, take the forgotten tablet as soon as you remember.

However, if it is almost time for your next scheduled dose (e.g., less than 12 hours), skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for the missed dose. Taking two doses close together can increase the risk of side effects, particularly excessive drowsiness. To ensure consistent allergy control, try to establish a routine of taking the medication at the same time every day.