Pregavit Capsule

Pregavit Capsule contains Benfotiamine, Pregabalin, Methylcobalamin (Vitamin B12), Pyridoxine (Vitamin B6), and Folic Acid (Vitamin B9), a fixed-dose combination formulated for the management of neuropathic pain and peripheral nerve damage. Pregabalin is a neuromodulator that calms overactive pain pathways in the nervous system. Benfotiamine is a highly bioavailable, fat-soluble derivative of Vitamin B1 that protects nerves from metabolic injury. Methylcobalamin, Pyridoxine, and Folic Acid are neurotropic B vitamins that support myelin synthesis, neurotransmitter production, and the biological regeneration of damaged nerve fibres. Together, this combination offers both symptomatic pain relief and active nerve repair in a single oral formulation. Always use Pregavit Capsule exactly as prescribed by your doctor.

Pregavit Capsule is a multi-component neurological combination medicine that pairs an anticonvulsant neuromodulator (Pregabalin) with four neurotropic B vitamins (Benfotiamine, Methylcobalamin, Pyridoxine, and Folic Acid). It is used in conditions where peripheral nerve damage produces chronic, difficult-to-treat pain — most notably diabetic peripheral neuropathy, post-herpetic neuralgia, alcoholic neuropathy, and chemotherapy-induced nerve injury.

Pregabalin reduces abnormal pain signalling by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the nervous system, limiting the release of excitatory neurotransmitters that drive neuropathic pain. Benfotiamine activates key metabolic enzymes that protect peripheral nerves from glucose-related damage. Methylcobalamin directly supports myelin production and axonal regeneration. Pyridoxine is essential for neurotransmitter synthesis and homocysteine metabolism. Folic Acid, working alongside Methylcobalamin, lowers elevated homocysteine levels that are independently associated with nerve damage.

The combination's strength lies in addressing neuropathic pain through two parallel strategies — controlling the pain signal neurologically while simultaneously providing the biological building blocks needed for nerve repair and long-term protection.

The uses of Pregavit Capsule are as follows:

Diabetic Peripheral Neuropathy

Relieves burning, tingling, shooting pain, and numbness in the feet, legs, and hands caused by nerve damage from chronic hyperglycaemia.

Post-Herpetic Neuralgia

Manages persistent nerve pain that continues after a healed shingles infection.

Alcoholic Neuropathy

Provides nerve support and pain relief in patients with nerve degeneration from chronic alcohol use and associated B vitamin depletion.

Chemotherapy-Induced Peripheral Neuropathy

Reduces tingling, numbness, and burning pain caused by neurotoxic chemotherapy agents.

Vitamin B Deficiency Neuropathy

Corrects nerve damage arising from deficiency of Vitamins B1, B6, or B12.

Fibromyalgia

Reduces widespread musculoskeletal nerve pain and improves sleep quality.

Radiculopathy

Adjunctive management of shooting or radiating pain from cervical or lumbar nerve root compression.

Idiopathic Peripheral Neuropathy

Symptomatic and supportive management of peripheral nerve disorders of mixed or undetermined cause.

Here are the benefits of Pregavit Capsule:

• Dual-Action Pain Control and Nerve Repair: Pregabalin calms overactive pain pathways while the B vitamin complex supplies the nutrients required for myelin restoration and nerve fibre regeneration, addressing both the symptom and the biological cause of nerve pain simultaneously.

• Targeted Protection in Diabetic Neuropathy: Benfotiamine's unique mechanism is redirecting excess glucose away from pathways that produce nerve-damaging compounds which makes this combination particularly effective for patients whose neuropathy is driven by chronic high blood sugar.

• Improved Sleep and Quality of Life: Neuropathic pain severely disrupts sleep. Pregabalin has well-established sleep-improving properties, helping patients achieve more restorative rest and reducing the fatigue and mood disturbance that accompany chronic nerve pain.

• Reduction of Neurotoxic Homocysteine: The combined action of Methylcobalamin, Pyridoxine, and Folic Acid actively lowers elevated plasma homocysteine, a compound that is independently toxic to peripheral nerves and associated with worsening neuropathy and cardiovascular risk.

Like all medicines, Pregavit Capsule may cause side effects in some individuals, although many people tolerate it well.

Common Side Effects:

• Dizziness and Drowsiness: The most frequently reported effects of Pregabalin; usually more pronounced at the start of treatment and improve with continued use.

• Weight Gain: Pregabalin may increase appetite, leading to gradual weight gain with prolonged use.

• Peripheral Oedema: Swelling of the feet or ankles, particularly in older patients or those with cardiovascular conditions.

• Headache, Nausea, and Dry Mouth: Mild and typically transient; taking the medicine with food helps reduce nausea.

• Blurred Vision: May occur at higher doses and usually resolves with dose stabilisation.

Serious Side Effects (Require Immediate Medical Attention):

• Suicidal Ideation or Mood Changes: Pregabalin, like all anticonvulsants, carries a rare risk of worsening depression or suicidal thoughts. Report any unusual mood changes to your doctor immediately.

• Severe Allergic Reaction: Facial swelling, hives, throat tightening, or difficulty breathing require emergency care.

• Significant Fluid Retention: Rapid or severe oedema, particularly with shortness of breath, requires urgent medical review.

• Respiratory Depression: Especially dangerous when combined with opioids or benzodiazepines; causes a dangerous reduction in breathing rate.

• Withdrawal Symptoms on Abrupt Discontinuation: Stopping Pregabalin suddenly can trigger anxiety, insomnia, nausea, sweating, and rebound pain. Always taper under medical supervision.

Always consult your doctor if you notice any unusual symptoms while taking Pregavit Capsule.

To ensure the best therapeutic effect and minimise side effects, Pregavit Capsule should always be taken exactly as advised by your doctor.

• Take Pregavit Capsule exactly as prescribed. Do not self-adjust the dose or stop it suddenly.

• May be taken with or without food; taking it after a meal reduces nausea and improves tolerability.

• Swallow tablets or capsules whole with a full glass of water.

• Pregabalin requires gradual dose titration. Your doctor will start low and increase slowly to minimise dizziness and drowsiness.

• Never take a double dose to compensate for a missed one.

• Avoid alcohol completely during the entire course of treatment.

• Always taper Pregabalin gradually before stopping, never discontinue abruptly.

• Inform your doctor of all other medicines you are taking, especially opioids, sedatives, or other CNS-active drugs.

Pregavit Capsule works through multiple complementary mechanisms targeting different aspects of nerve pain and nerve disease.

Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels at presynaptic nerve terminals in the spinal cord and brain. This reduces calcium influx, limiting the excessive release of excitatory neurotransmitters, including glutamate, norepinephrine, and substance P, that amplify pain signalling in neuropathic states. The result is a reduction in central and peripheral sensitisation and meaningful relief from burning, tingling, and shooting pain.

Benfotiamine, after conversion to thiamine pyrophosphate in the body, activates the enzyme transketolase and stimulates the pentose phosphate pathway. This redirects excess intracellular glucose away from damaging metabolic routes, including the polyol pathway and protein kinase C activation, that generate advanced glycation end-products, oxidative stress, and peripheral nerve injury.

Methylcobalamin is the neurologically active form of Vitamin B12 that nerve cells can utilise directly. It is essential for myelin basic protein synthesis, axonal regeneration, and the remethylation of homocysteine to methionine, a critical step in one-carbon metabolism and neuronal health.

Pyridoxine (Vitamin B6) functions as the coenzyme pyridoxal-5-phosphate, which is required for the synthesis of neurotransmitters including GABA, serotonin, and dopamine, as well as for the metabolism of homocysteine through the transsulphuration pathway.

Folic Acid (Vitamin B9), in its active form as 5-methyltetrahydrofolate, serves as the methyl donor for homocysteine remethylation alongside Methylcobalamin, supporting neuronal repair, DNA synthesis, and overall peripheral nerve health.

• Never stop Pregabalin suddenly. Always taper gradually under your doctor's guidance.

• Take the medicine at the same time each day for consistent nerve pain control.

• Strictly avoid alcohol throughout the course of treatment.

• Report any sudden changes in mood, behaviour, or thoughts to your doctor promptly.

• Maintain a balanced diet and regular light exercise to manage Pregabalin-related weight gain.

• Keep blood sugar tightly controlled if diabetic. This works synergistically with this medicine.

• Protect your feet from unnoticed injuries if you have diabetic neuropathy and reduced sensation.

• Attend regular follow-ups to assess response, kidney function, and dose adjustments.

• Store in a cool, dry place below 25°C, away from direct sunlight and moisture.

• Do not store in the bathroom or near a kitchen sink.

• Keep out of reach of children.

• Keep in its original packaging until use.

• Do not use after the expiry date printed on the label.

• Pregavit Capsule does not have significant interactions with most foods. However:

• Can generally be taken with or without food, although taking it after meals may improve stomach tolerance.

• Avoid excessive alcohol intake, as alcohol may increase dizziness, drowsiness, and may interfere with B-vitamin absorption.

• Maintain adequate hydration during treatment, especially if dry mouth occurs.

• Avoid excessive caffeine if it worsens nervousness or sleep disturbance.

Pregavit Capsule may interact with:

• Sedatives and sleeping medicines: May increase drowsiness and dizziness.

• Opioid painkillers: Can enhance sedation and breathing difficulty.

• Antidiabetic medicines: Blood sugar monitoring may still be needed during combined use.

• Antacids or acid-suppressing medicines: Long-term use may reduce Vitamin B12 absorption.

• Methotrexate: May interfere with folic acid metabolism.

• Levodopa (without carbidopa): Vitamin B6 may reduce levodopa effectiveness.

• ACE inhibitors or fluid-retaining medicines: May increase swelling risk with pregabalin.

Pregavit Capsule should be used carefully in:

• Kidney Disease: Pregabalin is eliminated mainly through the kidneys, so dose adjustment may be required.

• Heart Failure: Pregabalin may cause fluid retention and worsen symptoms in susceptible patients.

• Depression or Mood Disorders: Monitor carefully, as pregabalin may affect mood in some individuals.

• Peripheral Oedema: Existing swelling may increase during treatment.

• Anaemia of Unknown Cause: Vitamin B12 and folate supplementation should be used carefully until diagnosis is clear.

• Liver Disease: Use cautiously in significant hepatic impairment.

Dosing depends on the severity of neuropathy, patient age, and kidney function. Pregabalin is typically started at a low dose and titrated gradually over one to two weeks based on clinical response. The B vitamin components are present at fixed therapeutic doses in the combination. The formulation is usually taken once or twice daily, with or after food. Always follow your doctor's instructions precisely and never self-adjust the Pregabalin dose.

If you miss a scheduled dose, take it as soon as you remember, unless it is nearly time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Never take two doses at the same time. Consistent dosing is particularly important for the Pregabalin component, as irregular use may reduce pain control. Never stop Pregabalin suddenly without medical advice, as abrupt discontinuation can cause withdrawal symptoms including anxiety, insomnia, nausea, and rebound pain.