I started Semaglutide at 0.25mg for six weeks, then moved up to 0.5mg for four weeks, and I've noticed my appetite suppression has eased off and weight loss has slowed. Is that normal?

This is actually a pretty common pattern - the body adjusts a bit as it adapts to each dose, and appetite suppression can feel less dramatic over time even while the medicine keeps working. It doesn't necessarily mean it's stopped helping. Rather than increasing the dose on your own, check in with your doctor, since the next step up should be timed and monitored properly.