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Phenoxybenzamine

Uses

Phenoxybenzamine uses Phenoxybenzamine is used in the treatment of hypertension (high blood pressure).

How it Works

How Phenoxybenzamine works Phenoxybenzamine is an alpha blocker that helps reduce blood pressure in pheochromocytoma, a tumor of the adrenal gland. It works by opposing the action of certain hormones released from the tumor that cause blood vessels to narrow and raise blood pressure.

Expert Advice

  • Phenoxybenzamine can be taken with or without food, or as advised by your doctor.
  • Use it in conjunction with lifestyle modifications, including:
    • Regular exercise
    • A balanced diet
    • Smoking cessation
  • To reduce the risk of dizziness or fainting, rise slowly after sitting or lying down.
  • Be aware that it may cause dizziness or sleepiness.
  • Avoid driving or performing tasks that require concentration until you understand how it affects you.
  • Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

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Frequently asked questions

Phenoxybenzamine is contraindicated in individuals allergic to it and those with a recent history of stroke or heart attack (within the last month). Inform your doctor if any of these conditions apply.
Yes, Phenoxybenzamine can impact sexual function, potentially causing inhibition of ejaculation and impotence. These effects are usually mild and temporary. Discuss any concerns with your doctor.
Phenoxybenzamine may also be effective in treating Raynaud’s phenomenon, which causes discoloration of fingers and toes due to temperature changes or emotional events. It is also useful for treating frostbite.
Phenoxybenzamine should be taken as long as prescribed by your doctor. Do not discontinue use without consulting your doctor first, as long-term use may be associated with cancer risk. Always consult your doctor before starting treatment.
Phenoxybenzamine is an alpha receptor blocker that reduces resistance and increases blood flow to the skin, mucosa, and abdominal viscera, leading to lower blood pressure. This drop in blood pressure triggers reflex tachycardia due to increased noradrenaline release.
Phenoxybenzamine is used to manage high blood pressure caused by pheochromocytoma, a tumor of the adrenal glands that releases excess catecholamines. It blocks alpha receptors, resulting in decreased blood pressure.
An overdose of Phenoxybenzamine may lead to significant drops in blood pressure, increased heart rate, and possible collapse. If an overdose occurs, seek immediate medical attention.
Phenoxybenzamine offers a long duration of action, allowing for twice-daily dosing. It also prevents episodic catecholamine release during the pre- and post-operative periods, helping to maintain blood pressure control during surgery.