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Lenalidomide

Uses

Lenalidomide is used in the treatment of multiple myeloma and leprosy reactions.

How it Works

How Lenalidomide works Lenalidomide is an anti-cancer medication. It enhances the immune system, which indirectly attacks cancer cells. Additionally, it prevents the growth of new blood vessels within tumors and restricts the production of chemical messengers, such as cytokines and growth factors, that are responsible for the growth of cancer cells. This is how it works against cancer.

Side Effects

Common side effects of Lenalidomide include headache, nausea, rash, breathlessness, dizziness, fatigue, decreased white blood cell count (neutrophils), joint pain, insomnia (difficulty sleeping), itching, diarrhea, depression, high blood pressure, low blood platelets, lymphocytopenia, autoimmune hemolytic anemia, peripheral edema, cough, back pain, upper respiratory tract infection, urinary tract infection, decreased appetite, decreased potassium level in blood, increased alanine aminotransferase, increased aspartate aminotransferase, discomfort when urinating, palpitations, leukemia (blood cancer), decreased levels of thyroid hormones, bruising, falls, pneumonia, increased glucose level in blood, taste changes, and nasopharyngitis (inflammation of the throat and nasal passages).

Expert Advice

  • You may be monitored with regular blood tests before and during treatment, as lenalidomide may cause a decrease in white blood cells and platelets, which are essential for fighting infections, hemoglobin levels, and blood clotting.
  • Avoid activities that may lead to bruising or injury, and steer clear of contact with individuals who have colds or infections.
  • Lenalidomide can increase skin sensitivity to sunlight. Apply sunscreen or wear protective clothing when going outdoors.
  • This medication may cause dehydration. Drink plenty of water to stay hydrated while undergoing treatment.
  • Lenalidomide is not recommended for use in children and adolescents under 18 years of age.
  • Employ proper contraceptive methods at least 4 weeks before, during, and for 4 weeks after stopping treatment.
  • Women of childbearing potential will be required to undergo pregnancy tests before and after treatment.
  • Inform your doctor or dentist that you are taking lenalidomide before receiving any medical or dental care, emergency care, or surgery.
  • This medication may cause dizziness or sleepiness. Avoid driving or engaging in activities that require concentration until you know how it affects you.
  • You may be at risk of developing acute myelogenous leukemia, Hodgkin lymphoma, tumor lysis syndrome, fatal liver problems, severe skin reactions, and fatal heart issues during treatment with lenalidomide.
  • Discuss the benefits and risks of taking this medication with your healthcare provider in advance.

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Frequently asked questions

Patients with multiple myeloma receiving Lenalidomide in combination with melphalan and a blood stem cell transplant may have an increased risk of developing new cancers, including certain blood cancers and Hodgkin lymphoma. Discuss your cancer risk with your doctor if you are taking Lenalidomide.
Common side effects of Lenalidomide include diarrhea, constipation, stomach pain, loss of appetite, weight loss, weakness, dizziness, altered taste, and oral discomfort. Other effects may include numbness, sleep disturbances, depression, joint or muscle pain, excessive sweating, dry skin, abnormal hair growth in women, tremors, decreased libido, and urinary issues. Inform your doctor if any symptoms are severe or persistent.
Lenalidomide can be taken with or without food. Always follow your doctor's prescription. Swallow the capsules whole with water, without crushing, cutting, or chewing them. Take Lenalidomide at the same time on scheduled days.
Yes, Lenalidomide can be administered to dialysis patients after the dialysis session. However, the doctor may adjust the dosage as necessary.
Serious side effects of Lenalidomide include difficulty breathing or swallowing, hoarseness, facial swelling, seizures, skin rashes, irregular heartbeats, and severe skin reactions. Other serious effects may involve swollen glands, muscle cramps, upper abdominal pain, jaundice, fatigue, and changes in urination. Contact your doctor immediately if you experience any of these symptoms.
Women who can become pregnant must use two forms of birth control for 4 weeks before starting Lenalidomide, throughout treatment, and for 4 weeks after the last dose. Men must use latex condoms during treatment and for 4 weeks after, even if they have had a vasectomy.
Yes, blood tests are required before starting treatment and weekly for the first 8 weeks. After treatment, monthly blood tests may be necessary, as Lenalidomide can lower white blood cells and platelets.