Are two different branded prolonged-release tablets containing Quetiapine 100mg the same medicine?

It makes sense to want clarity here, especially with a medicine like this one. When two tablets share the same salt, strength and release form, quetiapine 100mg here, they're generally considered equivalent in intended effect. Quetiapine is used for serious mental health conditions though, so any change in what you're taking should go through your psychiatrist, who can confirm the switch won't disrupt your treatment plan.