Should I use an oral Acyclovir tablet or this Acyclovir 5% w/w cream for faster recovery from cold sores?

For mild, occasional cold sores, the topical cream often does the job, especially if applied right when you feel the tingling start. If your sores are more frequent, severe, or you're immunocompromised, an oral tablet tends to work faster and more thoroughly since it acts from within. Your doctor can look at your history and tell you which route makes more sense for you.