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Vitamin E deficiency

Synonyms

Also known as Alpha-tocopherol deficiency

Overview

Vitamin E, a fat-soluble antioxidant, protects cells from damage by fighting free radicals and supporting vision, fertility, immunity, and brain and nerve health. Vitamin E deficiency is rare and characterized by muscular pain, weakness, loss of control over body movement, difficulty walking, numbness, and vision problems. Vitamin E deficiency is often caused by issues that impair fat absorption, such as cystic fibrosis, liver disease, and Crohn's disease since vitamin E is fat-soluble. Premature infants and those with genetic disorders affecting vitamin E metabolism are also at higher risk. Vitamin E deficiency is typically treated with oral vitamin E supplements, adjusted to meet individual needs. Higher doses or specialized formulations may be prescribed in severe cases, especially for those with absorption issues.

Key Facts

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Symptoms

The deficiency of Vitamin E is rare and can be marked by the following signs and symptoms:

  • Muscular pain
  • Weakness
  • Difficulty in walking
  • Numbness and tingling
  • Loss of control of body movements
  • Vision problems
  • Weakened immune system
  • Loss of feeling in the arms and legs

Children may experience the following additional symptoms:

  • Hyporeflexia (decreased muscle response to stimuli)
  • Loss of position sense (reduced awareness of posture, weight, movement, and limb position)
  • Retinopathy (damage to the blood vessels of the eye)

Cause

Vitamin E is a crucial antioxidant that protects cell membranes from oxidative damage, supports immune function, and maintains skin and eye health.

When vitamin E is deficient, the body lacks this antioxidant protection, leading to increased oxidative stress, especially in nerve and muscle cells.

This can result in neurological symptoms, such as:

  • Muscle weakness
  • Coordination issues

Additionally, immune dysfunction can occur as cell membranes become more susceptible to damage.

Factors that can increase the risk of vitamin E deficiency are discussed below.

RiskFactors

1. Fat malabsorption

Vitamin E requires fat for absorption, so individuals with fat absorption issues are at higher risk of deficiency due to conditions like:

  • Chronic pancreatitis
  • Celiac disease
  • Cholestatic liver disease
  • Cystic fibrosis
  • Short bowel syndrome
  • Gall bladder disorders
  • Liver disorders

Liver disorders are increasing in India! A recent report suggests that 1 in every 3 people in India suffer from fatty liver. Want to know more about this condition? Read this.

2. Family History

One of the primary reasons for Vitamin E deficiency is genetic predisposition. This deficiency is often passed down through generations.

Note: If there is a history of Vitamin E deficiency in the family, it is crucial to monitor Vitamin E levels regularly.

3. Low birth weight

The likelihood of Vitamin E deficiency is high among newborns and premature babies with lower birth weights.

Premature babies often have underdeveloped digestive systems that can interfere with the absorption of fat and Vitamin E.

Premature baby at home? Here is how to care. Read now.

4. Age and Gender

Vitamin E deficiency is most common among the elderly and children due to limited dietary diversity and low fruit and vegetable intake.

Among adults, many studies have demonstrated a higher prevalence of Vitamin E deficiency in men than in women.

5. Environmental Factors

  • Obesity
  • Surgery
  • Low dietary intake of Vitamin E
  • Smoking

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Diagnosis

The diagnosis of Vitamin E deficiency includes:

  1. Medical history and physical examination

The medical practitioner analyzes potential risk factors and personal health history during screening for Vitamin E deficiency. The presence of various signs and symptoms is evaluated.

  1. Vitamin E (tocopherol) test

This test measures blood levels of Vitamin E, helping to detect deficiencies that may impact immune function, vision, and skin health.

  1. Imaging tests

These tests may be required to identify the underlying cause or the outcomes of Vitamin E deficiency.

  • X-rays: A prolonged Vitamin E deficiency can cause bone damage due to impaired calcium absorption. X-rays are used to assess bone density.
  • Magnetic resonance imaging (MRI): Severe deficiency of Vitamin E can damage nerves. MRI is used to examine the condition of the brain and spinal cord, particularly in the presence of symptoms such as numbness, tingling, or balance problems.

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Prevention

Here are a few tips suggested to avoid vitamin E deficiency:

  1. Add Vitamin E to your diet
    To meet these requirements, include plant-based oils, nuts, seeds, fruits, and vegetables that are sources of Vitamin E in your diet.
  2. Include good sources of fat
    Vitamin E cannot be absorbed without fat. It is important to include good sources of polyunsaturated fatty acids (PUFAs) in the diet. Some examples include:
    • Walnuts
    • Sunflower seeds
    • Flax seeds or flax oil
    • Fish, such as salmon, mackerel, herring, albacore tuna, and trout
    • Corn oil
    • Soybean oil
    • Safflower oil
  3. Increase the intake of Vitamin C
    Vitamin C helps support the antioxidant effects of Vitamin E. To maintain high levels of vitamin E, ensure you consume vitamin C-rich foods. If you are unable to meet the dietary intake of Vitamin C, consider our Vitamin C supplements after consulting with your doctor.
  4. Limit starch-containing foods
    People who consume a lot of starchy foods such as sweets, bread, and potatoes tend to have lower Vitamin E levels. Limit the amount of starch-containing foods and add green vegetables and nuts to your diet.

Treatment

The treatment of Vitamin E deficiency focuses on correcting the underlying cause, such as fat malabsorption, along with supplementation. Here are some common methods used to treat Vitamin E deficiency:

  • Dietary modifications

A modification in diet significantly aids in the treatment process. Individuals are advised to increase their intake of:

  • Leafy vegetables
  • Whole grains
  • Nuts
  • Seeds
  • Vegetable oils
  • Fortified cereals
  • Vitamin E supplementation

Oral supplements are typically prescribed in the form of tablets or soft gel capsules for mild to moderate deficiency. Severe Vitamin E deficiency due to genetic defects or chronic diseases requires lifelong supplementation with high doses of vitamin E to prevent nerve damage and other complications.

Intramuscular injections are recommended for individuals with issues related to the small intestine or oral ingestion.

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HomeCare

To obtain the recommended intake of Vitamin E, it is advisable to consume a diverse selection of foods, including the following options:

  • Sunflower Seeds (Soorajmukhi ke Beej): These are rich in vitamin E, making them an excellent snack to help prevent or address vitamin E deficiency.
  • How To Use It? Sprinkling sunflower seeds in yogurt, oatmeal, or salad can provide a variety of nutrients.
  • Almonds (Badam): Almonds are rich in vitamin E, providing a nutritious way to prevent or alleviate vitamin E deficiency.
  • Spinach (Palak): Spinach is loaded with vitamin E, making it a beneficial leafy green for boosting vitamin E levels.
  • Eggs (Ande): These are an excellent source of vitamin E, especially the egg yolks which contain higher levels of the nutrient compared to the whites.
  • Fortified Cereals: These include food items such as whole wheat and oats. They are also an excellent choice for vitamin E, and regular consumption can help raise vitamin E levels.
  • Milk and Other Dairy Products: Milk, along with cheese and paneer, is rich in vitamin E, protein, calcium, and minerals, and is absorbed quickly and easily in the stomach.

Complications

Vitamin E deficiency can lead to various complications and health problems. Here are some of the potential complications associated with Vitamin E deficiency:

  • Low immunity: Vitamin E deficiency impairs the immune response, making the body more prone to infectious and chronic diseases.
  • Cancer: Individuals with low Vitamin E lack its powerful endogenous anticancer properties. Low Vitamin E is associated with certain types of cancers, such as melanoma (skin cancer) and oral cancer.
  • Anemia: People with Vitamin E deficiency are prone to hemolytic anemia, which causes excessive red blood cell destruction.
  • Heart disease and stroke: Antioxidants like Vitamin E are crucial for a healthy heart and blood vessels. Vitamin E deficiency can lead to stroke or heart failure.
  • Reduced fertility: Vitamin E plays a vital role in reproductive health for both men and women. Low levels may reduce the chances of conception and successful pregnancy.
  • Vision problems: Lack of Vitamin E can cause vision loss by reducing the number of light receptors in the retina, leading to impaired vision over time.

Living With Disease

Living with Vitamin E deficiency requires careful management and attention to your diet and overall health. Here are some suggestions to help you live with a Vitamin E deficiency:

  • Take supplements regularly: To restore the levels, the doctor may prescribe oral or injectable supplements. Follow their dosage recommendations.
  • Monitor your diet: Maintain a food diary to track your Vitamin E intake and discover any inadequacies. This might help in identifying patterns and making appropriate adjustments.
  • Be aware of symptoms: Stay alert for any symptoms of Vitamin E deficiency and report any new symptoms to the doctor as soon as possible.
  • Go for regular check-ups: Schedule regular check-ups to monitor Vitamin E levels and get guidance on treatment adjustments as needed.
  • Be cautious of certain medications: People on blood thinners should avoid taking Vitamin E supplements as high levels may increase the risk of bleeding.

References

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Frequently asked questions

Yes, Vitamin E may enhance fertility by protecting reproductive cells and supporting overall reproductive health, improving sperm quality in men and balancing hormones in women.
Yes, Vitamin E is crucial for muscle health. A deficiency can result in muscle weakness, cramps, or loss of coordination due to nerve damage.
Yes, excessive Vitamin E can cause severe bleeding and other issues like muscle weakness, fatigue, nausea, and diarrhea. It's important to adhere to the recommended supplement dosage.
Taking Vitamin E within the recommended daily amount is safe, but supplements are usually unnecessary unless your diet is low in vitamin E or a doctor advises them.