Levocetirizine + Phenylephrine is a prescription combination medicine containing two active ingredients, Levocetirizine and Phenylephrine. Levocetirizine is an antihistamine that helps relieve allergy symptoms such as sneezing, runny nose, itchy throat, and watery eyes. Phenylephrine is a nasal decongestant that works by narrowing blood vessels in the nasal passages, thereby reducing nasal swelling and congestion. Together, these ingredients help provide relief from nasal congestion and allergy-associated symptoms related to the common cold, sinus congestion, and allergic rhinitis.

Levocetirizine + Phenylephrine combines two medicines that work together to relieve symptoms associated with allergies, the common cold, and nasal congestion.

Levocetirizine is a second-generation antihistamine that blocks histamine H1 receptors, helping reduce sneezing, runny nose, nasal itching, watery eyes, and throat irritation associated with allergic conditions. It generally causes less drowsiness compared to older antihistamines. Phenylephrine is a nasal decongestant that works by constricting blood vessels in the nasal passages, thereby reducing nasal swelling, sinus congestion, and stuffiness, helping improve breathing comfort.

This combination provides short-term relief from allergy and cold symptoms and should be used as advised by a healthcare professional. Caution is advised in patients with high blood pressure, heart disease, thyroid disorders, diabetes, or those taking other decongestants. Do not exceed the recommended dose, and seek medical advice if symptoms persist or worsen.

Common Cold and Allergic Rhinitis

Helps relieve symptoms such as sneezing, runny nose, blocked nose, nasal congestion, and watery eyes associated with cold and allergy conditions.

Nasal and Sinus Congestion

Helps reduce nasal blockage, sinus pressure, and stuffiness, improving breathing comfort.

Allergy-Associated Symptoms

Helps reduce nasal irritation, sneezing, throat irritation, and discomfort during allergic episodes.

• Dual-Action Symptom Relief: Provides relief from both allergy symptoms and nasal congestion in a single combination.

• Improves Breathing Comfort: By reducing nasal blockage and irritation, the combination may help improve breathing comfort during cold or allergy episodes.

• Supports Daytime Comfort: Levocetirizine is generally less sedating than older antihistamines, helping maintain better daytime comfort and routine activities.

When taken as directed, Levocetirizine + Phenylephrine is generally well tolerated. Side effects, if they occur, are usually mild and temporary.

Common Side Effects

• Mild drowsiness or sleepiness

• Headache

• Dry mouth

• Fatigue or tiredness

Uncommon Side Effects

• Dizziness

• Nausea or stomach discomfort

• Increased heart rate or nervousness (due to Phenylephrine)

• Skin rash or itching

Serious Side Effects (Require Immediate Medical Attention):

• Severe allergic reactions: Difficulty breathing, swelling of the face, lips, tongue, or throat, or severe skin rash

• Severe increase in blood pressure or palpitations

• Severe dizziness or chest discomfort

Levocetirizine + Phenylephrine is commonly available as tablets and syrup/oral liquid formulations.

• Adult Dosage: 1 tablet once or twice daily, as advised by the doctor.

• For liquid formulations, measure the dose using a dosing cup or spoon for accurate dosing. This medicine should be taken exactly as advised by the doctor, as the dose may vary depending on age, symptoms, and other supportive medicines being used.

• For pediatric drops, use a clean calibrated dropper for accurate dosing. Administer the medicine exactly as advised by the doctor.

Levocetirizine is a second-generation antihistamine that works by blocking histamine H1 receptors in the body. Histamine is a chemical released during allergic reactions and is responsible for symptoms such as sneezing, runny nose, watery eyes, nasal itching, and throat irritation. By preventing histamine from attaching to its receptors, Levocetirizine helps relieve these allergy-related symptoms and improves comfort during allergic conditions such as allergic rhinitis and the common cold. Compared to older antihistamines, it is generally associated with less drowsiness and is usually better tolerated at recommended doses.

Phenylephrine is a sympathomimetic nasal decongestant that acts primarily as an α1-adrenergic receptor agonist. It constricts blood vessels in the nasal passages, thereby reducing swelling, nasal congestion, and sinus pressure, which helps improve airflow and breathing comfort.

Together, these ingredients help relieve allergy symptoms and nasal congestion associated with the common cold, sinus irritation, and allergic rhinitis.

• Avoid Taking Other Cold or Allergy Medicines Together: Using multiple products with similar ingredients may increase the risk of side effects or accidental overdose.

• Stay Hydrated: Drinking enough fluids may help soothe throat irritation and improve comfort during cold or allergy conditions.

• Avoid Alcohol: Alcohol may increase drowsiness or dizziness caused by this medicine.

• Inform Your Doctor of All Medicines: Tell your doctor about all medicines you are taking to help avoid unwanted interactions.

• Food (Generally Safe): Levocetirizine + Phenylephrine may be taken with or without food. Taking it with food may help reduce stomach discomfort.

• Caffeine-Containing Drinks (Caution): Excessive intake of caffeine-containing beverages such as coffee, tea, or energy drinks may increase nervousness or palpitations in some individuals.

• MAO Inhibitors (Severe): Concurrent use may cause serious side effects such as severe increase in blood pressure.

• Other Cold or Allergy Medicines (Moderate): Using multiple medicines with similar ingredients may increase the risk of side effects or overdose.

• Antihypertensive Medicines (Moderate): Phenylephrine may reduce the effectiveness of some blood pressure-lowering medicines.

• Sedatives or CNS Depressants (Moderate): Concurrent use with sleeping pills or sedatives may increase drowsiness or dizziness.

• High Blood Pressure or Heart Disease (Moderate): Phenylephrine may increase blood pressure or heart rate. Use cautiously under medical supervision.

• Thyroid Disorders (Caution): Phenylephrine may worsen symptoms in patients with hyperthyroidism.

• Diabetes Mellitus (Caution): Use cautiously in diabetic patients, especially with syrup formulations that may contain sugar.

• Glaucoma (Moderate): Use cautiously in patients with narrow-angle glaucoma.

• Kidney or Liver Disease (Moderate): Dose adjustment may be required in patients with severe kidney or liver impairment.

Always follow the prescribed dose. Taking more than recommended of this medicine may cause excessive drowsiness, dizziness, nervousness, increased heart rate, nausea, or elevated blood pressure. In severe cases, confusion, severe palpitations, or difficulty breathing may occur. If an overdose is suspected, seek immediate medical attention.

Since Levocetirizine + Phenylephrine is typically taken as needed, a missed dose is usually not critical. If taken on a schedule, take the missed dose as soon as you remember, unless the next dose is due within 2 hours, then you can skip it. Never double the dose.