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Isotretinoin

Uses

Isotretinoin is used in the treatment of acne.

How it Works

Isotretinoin is a derivative of vitamin A. It acts on the sebaceous glands to reduce the production of sebum, a natural substance that contributes to acne. Additionally, controlled sebum production helps eliminate acne-causing bacteria. Isotretinoin also functions as an anti-inflammatory agent, decreasing inflammation, redness, and swelling.

Side Effects

Common side effects of Isotretinoin include dry skin, dry eyes, dermatitis, dry lips, nosebleeds, back pain, joint pain, headache, nasopharyngitis (inflammation of the throat and nasal passages), increased creatine phosphokinase levels in the blood, lip inflammation, and reduced visual acuity.

Expert Advice

  • You have been prescribed Isotretinoin for the treatment of severe acne.
  • Take it with food.
  • Avoid exposure to sunlight while using Isotretinoin.
  • Use protective measures such as sunscreen or protective clothing.
  • Avoid face waxing and laser treatments while using this medication, as it may make your skin more fragile.
  • Avoid taking tetracycline, as it may reduce the effectiveness of Isotretinoin.
  • Do not take Isotretinoin if you are pregnant, planning to become pregnant, or breastfeeding.
  • It may cause dryness of the mouth, lips, and eyes.
  • Drink plenty of water, use moisturizer, and avoid wearing contact lenses.
  • Inform your doctor if you experience any bothersome symptoms.

Other Combinations

Clindamycin + Isotretinoin

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Frequently asked questions

No, Isotretinoin is a retinoid (vitamin A) used to treat severe acne.
Isotretinoin should be used cautiously due to potential significant adverse reactions. It is intended for patients with severe nodular acne unresponsive to conventional treatments, including systemic antibiotics. Pregnant women must avoid it due to the risk of severe birth defects.
No, Isotretinoin has not been linked to cancer; it may even be beneficial for certain head, skin, and neck cancers.
Isotretinoin may cause a transient increase in liver enzymes, necessitating regular monitoring. These levels typically normalize over time, but persistent elevation may lead to discontinuation of the medication.
No, Isotretinoin does not impact male fertility, with no significant changes observed in ejaculate volume, sperm count, motility, morphology, or seminal plasma fructose.
Many patients experience lasting improvement after a single 15-20 week course. If a second course is needed, it should be initiated at least 8 weeks after the first, as symptoms may continue to improve post-treatment.
Isotretinoin poses a high risk of severe birth defects if pregnancy occurs during treatment.
Long-term effects of low doses have not been extensively studied, but Isotretinoin may affect bone mineral density, potentially leading to osteoporosis or fractures.
Liver enzymes and serum lipid levels are checked before treatment and monitored one month after starting, then every three months unless more frequent testing is clinically indicated.
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