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Allopurinol

Uses

Allopurinol is used in the treatment of gout.

How it Works

How Allopurinol Works Allopurinol is a xanthine oxidase inhibitor. It functions by reducing blood uric acid levels, which is the substance responsible for causing gout.

Side Effects

Common side effects of Allopurinol include rash.

Expert Advice

  • Your doctor has prescribed Allopurinol to reduce episodes of gout attacks.
  • Take Allopurinol with food to minimize the risk of stomach upset.
  • Ensure adequate fluid intake (2-3 liters) daily while on Allopurinol.
  • Notify your doctor if you develop a rash, as this could indicate an allergy and should resolve upon discontinuation of Allopurinol.
  • When you first start taking this medication, you may experience an increase in gout attacks.
  • Do not stop taking Allopurinol during an acute gout attack, as this may exacerbate the attack.
  • Your doctor may monitor your liver function before starting treatment and regularly thereafter.
  • Inform your doctor if you notice yellowing of the eyes or skin, dark urine, or abdominal pain.
  • Avoid alcohol consumption while taking this medication, as it may trigger a gout flare-up.

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Frequently asked questions

What is the optimal time to take Allopurinol?
Allopurinol can be taken at any time of day, but it is best to take it at the same time each day for consistency. It is usually prescribed once daily after meals. If the dose exceeds 300 mg or if you experience stomach upset, your doctor may recommend dividing the dose.
Can Allopurinol negatively affect liver health?
Yes, Allopurinol can cause liver issues. Your doctor may recommend blood tests to monitor liver function before and during treatment. Notify your doctor if you experience symptoms such as prolonged fatigue, loss of appetite, abdominal pain, dark urine, or jaundice.
Does Allopurinol cause drowsiness or dizziness?
Yes, Allopurinol may cause drowsiness, dizziness, or coordination issues in some individuals. It is best to avoid driving or operating machinery if you experience these side effects, and exercise caution if such activities are unavoidable.
Why might I still experience gout while on Allopurinol?
When starting Allopurinol, you may initially experience more frequent gout attacks. However, these attacks typically become shorter and less severe over time. This increase may be due to the breakdown of uric acid crystals, causing fluctuations in uric acid levels. To mitigate these attacks, your doctor may prescribe colchicine alongside Allopurinol.
Is Allopurinol considered an anti-inflammatory medication?
No, Allopurinol is not an anti-inflammatory drug. It is an enzyme inhibitor that reduces uric acid production by inhibiting xanthine oxidase, thereby decreasing gout attacks and potentially preventing uric acid kidney stones.
What are the effects of alcohol consumption while taking Allopurinol?
It is advisable to avoid alcohol while taking Allopurinol, as it can worsen your condition. Additionally, limit high-protein foods to help prevent gout attacks. Consult your doctor for a list of foods to avoid, and ensure you drink at least 8 glasses of water or other fluids unless otherwise directed by your doctor.
How long does it take for Allopurinol to effectively lower uric acid levels?
It may take several months to notice a significant reduction in gout attacks after starting Allopurinol. You may experience gout attacks initially, but continue taking the medication as prescribed. Consult your doctor if you need additional medications to manage these early attacks, as it may take years to eliminate all uric acid crystals.
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